Sr. Director, Oncology Programs Management

Project Leadership & Alliance Management · San Diego, California
Department Project Leadership & Alliance Management
Employment Type Full Time
Minimum Experience Senior Manager/Supervisor

Xencor is an innovative, clinical-stage biopharmaceutical company located in the Los Angeles area—near Pasadena—and in San Diego. We use our pioneering XmAb® technology to discover and develop better biotherapeutics, antibodies and cytokines with improved function, with the goal of improving patient outcomes and quality of life. We have an excellent opportunity for a Sr. Director, Oncology Programs Management to join our team.


Our protein engineering capabilities and the modular nature of our XmAb technology allow us to quickly identify and create new platforms and drug candidates for potential development. We are advancing a deep clinical pipeline of novel drug candidates, including eight bispecific antibodies and two engineered cytokines, and more programs are expected to start clinical testing in 2022. We also leverage our many XmAb technologies by collaborating with leading global biopharmaceutical companies, including Genentech and Janssen Biotech, among others, and including our partnerships, 20 XmAb drug candidates are advancing through clinical development. Three XmAb medicines, to treat patients with a range of serious illnesses, such as aggressive lymphoma, rare blood disorders and COVID-19, are now marketed worldwide by partners.


Our employees are the most important factor in our success, and we have assembled a highly talented group from diverse backgrounds and disciplines to execute our business plan and shape our future. Xencor employees’ value new ideas and flexibility and demand from each other scientific rigor, a passion for innovation, and a willingness to take risks.


This position can be based in San Diego or Monrovia and will be hybrid with 2-3 days onsite



Responsible for leadership of a cross-functional team which is accountable for the development of therapeutic oncology products in a global, matrix organization, from Discovery to life cycle management.

Job Duties Include:

  • Manages construction and maintenance of Integrated Development Plans, written in partnership with the program team and key experts
  • Influences functional team members to deliver on activities as necessary to achieve program goals
  • Provides periodic status reports to executives and coordinates documentation and archiving of project deliverables
  • Builds and drives a project team through clear designation of team roles, responsibilities, clear work scope and coordination of efforts
  • Communicates effectively across all functional groups so schedules and scope of the project remain clear
  • Provides alliance management support to one or more external partnerships
  • May provide oversight and direction to others as needed. When assigned, performs supervision in accordance with the organization’s policies and procedures which may include recruiting, training, communicating job expectations, appraising job performance, delivering feedback and coaching, and providing career development planning and opportunities
  • Manages project plans (in Smartsheet or MSP) that deliver the integrated development plan within agreed budget and timelines
  • Adheres to all department and company-wide policies regarding conduct, performance and procedures
  • Performs other duties as required.




Position requires a MS degree in Life Sciences or a related field, MBA or PhD preferred, and minimum of 12 years of related experience with at least 5 of those years including people management experience. Pre-IND to Phase 1 and 2 experience required, Phase 3 and commercial product experience strongly preferred. Knowledge and expertise in the areas of oncology, autoimmune disease, monoclonal antibody and global IND/BLA requirements strongly preferred.  Alliance experience preferred.

The company reserves the right to consider internal experience in lieu of the education or experience requirements listed above.


Position also requires:

  • Ability to successfully resolve program challenges through team-based problem solving and program tracking
  • Ability to use written and verbal communication skills to communicate complex scientific, medical and program issues
  • Operates with an attention to detail and understanding that details serve the higher-level strategy
  • Confidence and ability to professionally share opinions while valuing and respecting functional SME’s
  • Ability to partner with cross-functional team from research, pre-clinical development, manufacturing, quality, regulatory and clinical development
  • Strong leadership, influencing capability and active facilitation skills to enable effective team meetings and high-performance teams
  • Outstanding flexibility and adaptability suited for the changing requirements and fast pace of a small biotechnology company
  • Ability to effectively manage others through coaching and supervision, in accordance with company policies and practices. Ensures employee performance meets the organization’s expectations for conduct, productivity, quality, continuous improvement, and goal accomplishment.

Physical, Mental and Environment Demands:

The physical, mental and working environment demands described are representative of those that must be met by an employee to successfully perform the primary functions of this position.


The physical demands of the office are normally associated with extended amounts of time sitting and using office equipment, including a computer, keyboard and mouse, which can cause muscle strain. While performing the duties of this job, the employee is frequently required to stand, walk and sit. Periodic light lifting of supplies and materials may apply.


Specific mental demands for the position are listed above under requirements.  In addition, mental demands for this position include:

  • Ability to multitask without loss of efficiency or accuracy, including the ability to perform multiple duties from multiple sources.
  • Ability to work and sustain attention with distractions and/or interruptions.
  • Ability to interact appropriately with a variety of individuals including vendors, customers and clients.
  • Ability to maintain regular attendance and be punctual.
  • Ability to understand, remember and follow verbal and written instructions.

Occasional travel may be required, including travel between Xencor’s Monrovia and San Diego offices. Work for this position is generally performed at Xencor’s worksite and requires full-time commitment.


Xencor requires all employees to be fully vaccinated against COVID-19 as a condition of employment.  Being fully vaccinated means that at least two weeks have passed since an individual’s final dose of an authorized COVID-19 vaccine regimen, including any boosters recommended by the CDC.  New employees will be required to provide proof of their fully COVID-19 vaccinated status as of their start date unless an exemption or accommodation is approved. 

Americans with Disabilities Act (ADA) Statement

The Company will provide reasonable accommodations (such as a qualified sign language interpreter or other personal assistance) with the application process upon your request as required to comply with applicable laws. If you have a disability and require assistance in this application process, please contact


To perform this job successfully, an individual must be able to perform each essential duty satisfactorily. Reasonable Accommodations may be made to enable qualified individuals with disabilities to perform the essential functions.


Equal Employment Opportunity (EEO) Statement

The Company is an equal opportunity employer, and all qualified applicants will receive consideration for employment without regard to age, race, color, religion, sex, sexual orientation, gender or gender identity, national origin, disability status, protected veteran status or any other characteristic protected by state or federal law.


Xencor does not accept profiles or resumes from recruiting vendors without a binding written agreement. Any unsolicited submission of services and or resumes in no way creates an obligation or duty by Xencor, implied or otherwise.


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  • Location
    San Diego, California
  • Department
    Project Leadership & Alliance Management
  • Employment Type
    Full Time
  • Minimum Experience
    Senior Manager/Supervisor