Project Manager, Oncology Project Manager

Project Leadership & Alliance Management · San Diego, California
Department Project Leadership & Alliance Management
Employment Type Full Time
Minimum Experience Experienced

Xencor is an innovative, clinical-stage biopharmaceutical company located in the Los Angeles area—near Pasadena—and in San Diego. We use our pioneering XmAb® technology to discover and develop better biotherapeutics, antibodies and cytokines with improved function, with the goal of improving patient outcomes and quality of life. We have an excellent opportunity for a Project Manager to join our team.


Our protein engineering capabilities and the modular nature of our XmAb technology allow us to quickly identify and create new platforms and drug candidates for potential development. We are advancing a deep clinical pipeline of novel drug candidates, including eight bispecific antibodies and two engineered cytokines, and more programs are expected to start clinical testing in 2022. We also leverage our many XmAb technologies by collaborating with leading global biopharmaceutical companies, including Genentech and Janssen Biotech, among others, and including our partnerships, 20 XmAb drug candidates are advancing through clinical development. Three XmAb medicines, to treat patients with a range of serious illnesses, such as aggressive lymphoma, rare blood disorders and COVID-19, are now marketed worldwide by partners.


Our employees are the most important factor in our success, and we have assembled a highly talented group from diverse backgrounds and disciplines to execute our business plan and shape our future. Xencor employees’ value new ideas and flexibility and demand from each other scientific rigor, a passion for innovation, and a willingness to take risks.


This will be a hybrid position with 2 days on-site in our San Diego office.



Responsible for the generation, management, and maintenance of high-quality project schedules associated with programs in research and in clinical development to enable alignment of functional plans with corporate goals and priorities.

Job Duties Include:

  • Within a cross-functional team environment, contributes, leads or co-leads moderately complex sub-team project initiatives
  • Plays an integral role in supporting the management of evolving priorities within the portfolio
  • Coordinates, monitors and reports project schedule and resource management information to enable alignment of functional schedules and FTE/dollar resources into the project macro view
  • Supports delivery of pre-IND programs by constructing scoped investment modules for emerging programs then supporting their management as priorities evolve
  • Produces ‘what-if’ scenario analyses (base, optimistic and pessimistic development) based on context obtained from project team members
  • Monitors progress of project activities towards next project milestone, anticipates and highlights potential variances, supports line/team in critical path analyses and understanding the impact, and partners with the program PM, Clinical Operations, and the project team to support issue mitigation
  • Performs scenario planning of project timelines within and across protocols and across therapeutic area/portfolio to enable optimum use of local, global, and outsourced resources to ensure efficient delivery of project milestones
  • Contributes to risk management through the identification of operational and project/program risks for discussion with appropriate team leadership
  • Participates in team discussions to de-risk projects and develop new options to resolve moderately complex issues
  • Provides appropriate support to enable effective portfolio management activities
  • Utilizes available reporting and visualization tools to support governance and team reporting needs
  • Contributes to continuous improvement of project plans, plan generation, plan utilization, and/or report creation/development processes
  • Supports team documents (e.g., minutes) and other PM activities as needed
  • Adheres to all department and company-wide policies regarding conduct, performance and procedures
  • Performs other duties as assigned.



Position requires a BS/BA in a Life Science or related discipline, and a minimum of 5 years in project planning/project management and applicable pharmaceutical industry experience. Pre-IND to Phase 1 and 2 experience also required. Requires experience with planning tools (e.g., Smartsheet, MS Project, SharePoint), office software (e.g., MS Office, Business Objects, Spotfire). Experience and knowledge in oncology or autoimmune disease, monoclonal antibody expertise, global IND/BLA requirements preferred.


The company reserves the right to consider internal experience in lieu of the education or experience requirements listed above.


Position also requires:

  • Ability to partner and negotiate with cross-functional teammates from research, pre-clinical development, manufacturing, quality, regulatory clinical operations and clinical development
  • Strong attention to detail oriented and values details which serve the higher-level strategy
  • Understanding of the cross functional needs to advance a program through preclinical and clinical development stages
  • Ability to successfully resolve challenges through team-based problem solving and program tracking
  • Outstanding flexibility and adaptability suited for the changing requirements and fast pace of a small biotechnology company.


Physical, Mental and Environment Demands:

The physical, mental and working environment demands described are representative of those that must be met by an employee to successfully perform the primary functions of this position.


The physical demands of the office are normally associated with extended amounts of time sitting and using office equipment, including a computer, keyboard and mouse, which can cause muscle strain. While performing the duties of this job, the employee is frequently required to stand, walk and sit. Periodic light lifting of supplies and materials may apply.


Specific mental demands for the position are listed above under requirements.  In addition, mental demands for this position include:

  • Ability to multitask without loss of efficiency or accuracy, including the ability to perform multiple duties from multiple sources.
  • Ability to work and sustain attention with distractions and/or interruptions.
  • Ability to interact appropriately with a variety of individuals including vendors, customers and clients.
  • Ability to maintain regular attendance and be punctual.
  • Ability to understand, remember and follow verbal and written instructions.

Occasional travel may be required, including travel between Xencor’s Monrovia and San Diego offices. Work for this position is generally performed at Xencor’s worksite and requires full-time commitment.


Xencor requires all employees to be fully vaccinated against COVID-19 as a condition of employment.  Being fully vaccinated means that at least two weeks have passed since an individual’s final dose of an authorized COVID-19 vaccine regimen, including any boosters recommended by the CDC.  New employees will be required to provide proof of their fully COVID-19 vaccinated status as of their start date unless an exemption or accommodation is approved. 

Americans with Disabilities Act (ADA) Statement

The Company will provide reasonable accommodations (such as a qualified sign language interpreter or other personal assistance) with the application process upon your request as required to comply with applicable laws. If you have a disability and require assistance in this application process, please contact


To perform this job successfully, an individual must be able to perform each essential duty satisfactorily. Reasonable Accommodations may be made to enable qualified individuals with disabilities to perform the essential functions.


Equal Employment Opportunity (EEO) Statement

The Company is an equal opportunity employer, and all qualified applicants will receive consideration for employment without regard to age, race, color, religion, sex, sexual orientation, gender or gender identity, national origin, disability status, protected veteran status or any other characteristic protected by state or federal law.


Xencor does not accept profiles or resumes from recruiting vendors without a binding written agreement. Any unsolicited submission of services and or resumes in no way creates an obligation or duty by Xencor, implied or otherwise.


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  • Location
    San Diego, California
  • Department
    Project Leadership & Alliance Management
  • Employment Type
    Full Time
  • Minimum Experience