Sr. Research Associate, Immuno-Oncology

Discovery Biology & Pharmacology · Monrovia, California
Department Discovery Biology & Pharmacology
Employment Type Full Time
Minimum Experience Mid-level

We currently have an excellent opportunity for a talented Sr. Research Associate with Immuno-Oncology experience to join our team!

Xencor is an innovative, clinical-stage biopharmaceutical company located in the Los Angeles area—near Pasadena—and in San Diego. We use our pioneering XmAb® technology to discover and develop better biotherapeutics, antibodies and cytokines with improved function, with the goal of improving patient outcomes and quality of life.


Our protein engineering capabilities and the modular nature of our XmAb technology allow us to quickly identify and create new platforms and drug candidates for potential development. We are advancing a deep clinical pipeline of novel drug candidates, including eight bispecific antibodies and two engineered cytokines, and more programs are expected to start clinical testing in 2022. We also leverage our many XmAb technologies by collaborating with leading global biopharmaceutical companies, including Genentech and Janssen Biotech, among others, and including our partnerships, 20 XmAb drug candidates are advancing through clinical development. Three XmAb medicines, to treat patients with a range of serious illnesses, such as aggressive lymphoma, rare blood disorders, and COVID-19, are now marketed worldwide by partners.


Our employees are the most important factor in our success, and we have assembled a highly talented group from diverse backgrounds and disciplines to execute our business plan and shape our future. Xencor employees value new ideas and flexibility and demand from each other scientific rigor, a passion for innovation, and a willingness to take risks.



Responsible for providing support and contributing to daily laboratory operations, supporting efforts to identify therapeutic antibody candidates using specialized methods specific to the assigned group, function or department.


Job Responsibilities and Duties:

  • Contributes to research team efforts toward designing and running experiments, analyzing results, and interpreting data
  •  Develops, conducts, and troubleshoots various immunological and cellular bioassays including proliferation, apoptosis, viability, activation, and cytotoxicity assays using various read-outs including flow cytometry, luminescence, fluorescence, and ELISA, to deliver PK, ADA, biomarker and potency data in support of research and GxP studies
  • Supports efforts to implement, execute and report studies focused on identifying therapeutic antibody and protein candidates in the areas of oncology, inflammation and autoimmune disease.
  • Follows developing and established standard operating procedures in a regulated laboratory (GMP)
  • Maintains chemical inventory, laboratory equipment and related supplies
  • Maintains compliant records
  • Documents experimental protocols, designs, and results in a laboratory notebook
  • Employs computer programs to collect and analyze data
  • Analyzes and reports data, adhering to previously established timelines
  • Communicates data to team members
  • Helps prepare SOPs, presentations and technical reports
  • May help present data to management in departmental or companywide meetings
  • Follows all laboratory safety guidelines, practices and protocols
  • Coordinates and collaborates on research-related tasks across multiple groups
  • Adheres to all department and company-wide policies regarding conduct, performance and procedures
  • Performs other duties as required.


Job Qualifications:

  • Position requires a Bachelor’s degree in biological sciences, cell biology, immunology or a related field. An MS degree is preferred.
  • At least 5 years of prior related laboratory work experience in an industry setting is also required.
  • Proficiency in common software and data analysis packages such as SoftMax Pro, GraphPad Prism, JMP, and Spotfire and Microsoft Office (PowerPoint, Excel, Word, Outlook)
  • Ability to work in a fast-paced, goal-oriented multi-project environment
  • Detail orientation, good documentation practice and strong organizational skills
  • Strong interpersonal skills; ability to work well in a team as well as independently
  • Excellent oral and written communication skills
  • Well-organized, detail-oriented, able to work both independently and in a team setting, have excellent oral and written communication skills and be available for work on weekends
  • Ability to perform method development, write protocols, maintain detailed records and inventory are required
  • Ability to adapt to changing priorities


Physical, Mental and Environment Demands:

The physical, mental and working environment demands described are representative of those that must be met by an employee to successfully perform the primary functions of this position.


The physical demands of the office are normally associated with extended amounts of time sitting and using office equipment, including a computer, keyboard and mouse, which can cause muscle strain. While performing the duties of this job, the employee is frequently required to stand, walk and sit. Periodic light lifting of supplies and materials may apply.


Specific mental demands for the position are listed above under requirements. In addition, mental demands for this position include:


  • Ability to multitask without loss of efficiency or accuracy, including the ability to perform multiple duties from multiple sources.
  • Ability to work and sustain attention with distractions and/or
  • Ability to interact appropriately with a variety of individuals including vendors, customers and clients.
  • Ability to maintain regular attendance and be
  • Ability to understand, remember and follow verbal and written


Work for this position is performed at Xencor’s worksite and requires full-time commitment.


Xencor requires all employees to be fully vaccinated against COVID-19 as a condition of employment. Being fully vaccinated means that at least two weeks have passed since an individual’s final dose of an authorized COVID-19 vaccine regimen, including any boosters recommended by the CDC. New employees will be required to provide proof of their fully COVID- 19 vaccinated status as of their start date unless an exemption or accommodation is approved.


Americans with Disabilities Act (ADA) Statement

The Company will provide reasonable accommodations (such as a qualified sign language interpreter or other personal assistance) with the application process upon your request as required to comply with applicable laws. If you have a disability and require assistance in this application process, please contact


To perform this job successfully, an individual must be able to perform each essential duty satisfactorily. Reasonable Accommodations may be made to enable qualified individuals with disabilities to perform the essential functions.


Equal Employment Opportunity (EEO) Statement

The Company is an equal opportunity employer, and all qualified applicants will receive consideration for employment without regard to age, race, color, religion, sex, sexual orientation, gender or gender identity, national origin, disability status, protected veteran status or any other characteristic protected by state or federal law.


Xencor does not accept profiles or resumes from recruiting vendors without a binding written agreement. Any unsolicited submission of services and or resumes in no way creates an obligation or duty by Xencor, implied or otherwise.

Thank You

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  • Location
    Monrovia, California
  • Department
    Discovery Biology & Pharmacology
  • Employment Type
    Full Time
  • Minimum Experience