Research Associate 2 or 3

Discovery Biology & Pharmacology · Monrovia, California
Department Discovery Biology & Pharmacology
Employment Type Full Time
Minimum Experience Mid-level

Xencor is an innovative, clinical-stage biotechnology company located in the Los Angeles area (near Pasadena) and in San Diego. We use our pioneering XmAb® technology to discover and develop better biotherapeutics – antibodies and other proteins with improved function – with the goal of improving patient outcomes and quality of life, and we have an excellent opportunity for an experienced Research Associate 2/3.


Our protein engineering capabilities and the modular nature of our technology allow us to quickly identify and create new platforms and drug candidates for potential development. We are developing a broad portfolio enabled by the rapid expansion of our bispecific technologies, and nine XmAb bispecific antibodies and cytokines are in clinical testing. We also leverage our many XmAb technologies by engaging in multiple collaborations with leading global biopharmaceutical companies, including Novartis, Amgen and Genentech, among others. Including our partners, over a dozen XmAb drug candidates are advancing through clinical development, and the first antibody that incorporates an XmAb technology has been approved for commercial marketing worldwide.


Our employees are the most important factor in our success, and we have assembled a highly talented group from diverse backgrounds and disciplines to execute our business plan and shape our future. Xencor employees’ value new ideas and flexibility and demand from each other scientific rigor, a passion for innovation, and a willingness to take risks.


We currently have an excellent opportunity for a talented Research Associate 2/3 to join our team!  


The Discovery Biology and Pharmacology group is seeking an innovative and highly motivated Research Associate 2/3 with experience in immunology to join our team. In this lab-based role, the successful candidate will be responsible for designing and delivering biological data to support preclinical development of immune-based therapies for cancer and other diseases.

We are seeking to expand assay and analytical capabilities at a growing site to support novel multi-specific protein-based therapeutics efforts by characterize immune cell function. Applying a translational mindset, you will work in a dynamic and collaborative environment to interrogate mechanisms of action and pharmacology of novel therapeutics from early discovery to IND stages of programs.

We are looking for a creative, proactive experimentalist with a deep curiosity and enthusiasm for biology and therapeutics. You will be accountable for generating quality data using robust methodologies and must have the ability to work effectively both independently and as part of a larger team. Additionally, our team places high value on inclusivity and seeks team players that are open to the ideas of others.

Duties & Responsibilities

  • Perform a wide range of complex lab procedures including, but not limited to, peripheral blood mononuclear cell isolation, tissue culture (cell lines and primary human/cyno cells), human primary T cell stimulation assays, multiparameter flow cytometry immunophenotyping, monoclonal antibody conjugation, cell line generation.
  • Conduct independent research with minimal guidance, including planning and conduct of experiments which may require examination of peer reviewed publications to identify appropriate experimental strategies.
  • Maintain accurate, daily records of experiments.
  • Analyze experimental data, prepare summary analyses for presentation and/or publication, and participate in authorship of technical reports for IND submissions.
  • Participate in inventory management and ordering and maintenance of supplies
  • Calibrate and operate a variety of laboratory instruments under standard guidelines and following Standard Operating Procedures including Incucyte, flow cytometers, plate readers, cell counters, and automated liquid handlers.
  • Interact with scientists from other groups or departments involved in similar or related research projects.


  • A Bachelor’s degree plus three (>3) years of experience required.
  • Minimum of three (3) years of laboratory-based training in Immunology or a closely related field.
  • Extensive experience with all aspects of flow cytometry including instrument standardization, calibration, and assay optimization required.
  • Experience performing a variety of laboratory procedures including immune cell-based functional assays required.
  • Experience with human and monkey immune cells preferred.
  • Excellent communication skills (verbal and written) required.

Physical, Mental and Environment Demands:

The physical, mental and working environment demands described are representative of those that must be met by an employee to successfully perform the primary functions of this position.


The physical demands of the office are normally associated with extended amounts of time sitting and using office equipment, including a computer, keyboard and mouse, which can cause muscle strain. While performing the duties of this job, the employee is frequently required to stand, walk and sit. Periodic light lifting of supplies and materials may apply.


Specific mental demands for the position are listed above under requirements.  In addition, mental demands for this position include:

  • Ability to multitask without loss of efficiency or accuracy, including the ability to perform multiple duties from multiple sources.
  • Ability to work and sustain attention with distractions and/or interruptions.
  • Ability to interact appropriately with a variety of individuals including vendors, customers and clients.
  • Ability to maintain regular attendance and be punctual.
  • Ability to understand, remember and follow verbal and written instructions.

Occasional travel may be required, including travel between Xencor’s Monrovia and San Diego offices. Work for this position is generally performed at Xencor’s worksite and requires full-time commitment.


 Americans with Disabilities Act (ADA) Statement

The Company will provide reasonable accommodations (such as a qualified sign language interpreter or other personal assistance) with the application process upon your request as required to comply with applicable laws. If you have a disability and require assistance in this application process, please contact


To perform this job successfully, an individual must be able to perform each essential duty satisfactorily. Reasonable Accommodations may be made to enable qualified individuals with disabilities to perform the essential functions.


Equal Employment Opportunity (EEO) Statement

The Company is an equal opportunity employer, and all qualified applicants will receive consideration for employment without regard to age, race, color, religion, sex, sexual orientation, gender or gender identity, national origin, disability status, protected veteran status or any other characteristic protected by state or federal law.


Xencor does not accept profiles or resumes from recruiting vendors without a binding written agreement. Any unsolicited submission of services and or resumes in no way creates an obligation or duty by Xencor, implied or otherwise.


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  • Location
    Monrovia, California
  • Department
    Discovery Biology & Pharmacology
  • Employment Type
    Full Time
  • Minimum Experience