Scientist / Lead Scientist, Protein Biophysics

Discovery Biology & Pharmacology · Monrovia, California
Department Discovery Biology & Pharmacology
Employment Type Full Time
Minimum Experience Experienced

Xencor is an innovative, clinical-stage biotechnology company located in the Los Angeles area (near Pasadena) and in San Diego. We use our pioneering XmAb® technology to discover and develop better biotherapeutics – antibodies and other proteins with improved function – with the goal of improving patient outcomes and quality of life, and we have an excellent opportunity for a highly motivated Scientist to join our Biophysical and Bioanalytical Characterization Team.

Our protein engineering capabilities and the modular nature of our technology allow us to quickly identify and create new platforms and drug candidates for potential development. We are developing a broad portfolio enabled by the rapid expansion of our bispecific technologies, and nine XmAb bispecific antibodies and cytokines are in clinical testing. We also leverage our many XmAb technologies by engaging in multiple collaborations with leading global biopharmaceutical companies, including Novartis, Amgen and Genentech, among others. Including our partners, over a dozen XmAb drug candidates are advancing through clinical development, and the first antibody that incorporates an XmAb technology has been approved for commercial marketing worldwide.

Our employees are the most important factor in our success and we have assembled a highly talented group from diverse backgrounds and disciplines to execute our business plan and shape our future. Xencor employees value new ideas and flexibility and demand from each other scientific rigor, a passion for innovation, and a willingness to take risks.

Job Summary:

We are seeking a skilled biochemist for our Monrovia location to join the Biophysical and Bioanalytical Characterization team. The successful candidate will play a key role in the characterization of the biophysical properties of our pipeline of exciting pre-clinical antibody variants and assist in developing new assays as needed.

Primary Job Responsibilities:

  • Expand the biophysical characterization efforts at Xencor
  • Support the antibody discovery and engineering processes at Xencor through real-time binding characterization and data fitting
  • Support molecule thermostability and developability characterization and data fitting
  • Communicate results through detailed record keeping, summary reports and presentations
  • Collaborate on biotherapeutics projects with a project lead - from conception to therapeutic candidate nomination and IND filing
  • Contribute to the scientific direction and project vision
  • Accomplish goals under project team timelines
  • Instrument maintenance and other general lab duties


Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.


Please note this job description is not designed to cover or contain a comprehensive listing of activities, duties or responsibilities that are required of the employee for this job. Duties, responsibilities, and activities may change at any time with or without notice.


  • D. in Biochemistry, Biophysics, Chemical Biology or related field is required.
  • 2 to 4+ years relevant hands-on experience required.
  • Previous experience in a biotech environment is desired.
  • Previous management experience is a strong plus
  • Hands on experience with assay design, data collection and data fitting for a variety of binding, thermostability and developability assays (i.e. DSF, DSC, DLS, SPR, BLI, etc.)
  • Experience with high throughput liquid handling is a plus
  • Excellent time management, record keeping and organizational skills
  • Ability to work well in a multidisciplinary team.
  • Self-Motivated, strong inter-personal and communication skills.
  • Ability to work in a dynamic and fast-paced environment.

Physical, Mental and Environment Demands:

The physical, mental and working environment demands described are representative of those that must be met by an employee to successfully perform the primary functions of this position.


The physical demands of the office are normally associated with extended amounts of time sitting and using office equipment, including a computer, keyboard and mouse, which can cause muscle strain. While performing the duties of this job, the employee is frequently required to stand, walk and sit. Periodic light lifting of supplies and materials may apply.


Specific mental demands for the position are listed above under requirements.  In addition, mental demands for this position include:

  • Ability to multitask without loss of efficiency or accuracy, including the ability to perform multiple duties from multiple sources.
  • Ability to work and sustain attention with distractions and/or interruptions.
  • Ability to interact appropriately with a variety of individuals including vendors, customers and clients.
  • Ability to maintain regular attendance and be punctual.
  • Ability to understand, remember and follow verbal and written instructions.

Occasional travel may be required, including travel between Xencor’s Monrovia and San Diego offices. Work for this position is generally performed at Xencor’s worksite and requires full-time commitment.


Americans with Disabilities Act (ADA) Statement

The Company will provide reasonable accommodations (such as a qualified sign language interpreter or other personal assistance) with the application process upon your request as required to comply with applicable laws. If you have a disability and require assistance in this application process, please contact


To perform this job successfully, an individual must be able to perform each essential duty satisfactorily. Reasonable Accommodations may be made to enable qualified individuals with disabilities to perform the essential functions.


Equal Employment Opportunity (EEO) Statement

The Company is an equal opportunity employer, and all qualified applicants will receive consideration for employment without regard to age, race, color, religion, sex, sexual orientation, gender or gender identity, national origin, disability status, protected veteran status or any other characteristic protected by state or federal law.


Xencor does not accept profiles or resumes from recruiting vendors without a binding written agreement. Any unsolicited submission of services and or resumes in no way creates an obligation or duty by Xencor, implied or otherwise.

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  • Location
    Monrovia, California
  • Department
    Discovery Biology & Pharmacology
  • Employment Type
    Full Time
  • Minimum Experience