Scientist Molecular Biology - Antibody Discovery

Research · Monrovia, California
Department Research
Employment Type Full Time
Minimum Experience Experienced

Xencor is an innovative, clinical-stage biopharmaceutical company located in the Los Angeles area (near Pasadena) and in San Diego. We use our pioneering XmAb® technology to discover and develop better biotherapeutics – antibodies and other proteins with improved function – with the goal of improving patient outcomes and quality of life, and we have an excellent opportunity for a Scientist with a Molecular Biology background to join our Antibody Discovery team.


Our capabilities and the modular nature of XmAb technology allows us to quickly identify and create new platforms and drug candidates for potential development. We are developing a deep pipeline of novel drug candidates enabled by the rapid expansion of our bispecific antibody and cytokine technologies. Nine XmAb bispecific antibody programs are in clinical testing, and more are expected to start clinical testing in 2021. We also leverage our many XmAb technologies by engaging in multiple collaborations with leading global biopharmaceutical companies, including Novartis, Amgen and Genentech, among others. We and our partners are advancing 18 XmAb drug candidates through clinical development, and two medicines that incorporate XmAb technology are approved for commercial marketing.


Job Summary:

We are looking for a highly motivated Scientist to advance the B-cell and NGS focused Antibody Discovery efforts at Xencor. This is an exciting opportunity to make a significant impact within a group that is driving the discovery of advanced biologics therapeutics. The successful candidate is expected to develop and utilize multiple technologies including microfluidics, Single B-cell Cloning and Next Generation Sequencing to generate, characterize, and deliver sequence diversified and high-quality antibody lead candidates. The candidate will collaborate closely with project leads to understand the target biology and therapeutic molecule progress in the research and development portfolio.

Job Duties and Responsibilities:

  • Optimize the existing single B cell, microfluidics and NGS platforms towards a high performing, robust antibody lead delivery with seamless connection to downstream groups.
  • Advance automation to increase efficiency and match future demand
  • Co-lead new biotherapeutics projects in close collaboration with a project lead - from conception to therapeutic candidate nomination
  • Drive the science and contribute to the vision in and technology development of single cell cloning and gene capture
  • Excellent written and oral skills are necessary
  • Accomplish goals under project team timelines

Job Qualifications and Requirements:

  • Ph.D. in molecular biology or immunology with 2-4 years of industry experience or other relevant experience
  • High proficiency in all critical molecular biology techniques (RT-PCR, cloning, sequence analysis and mammalian transient transfection) with focus on high throughput, high sensitivity gene rescue from single cells or tissues
  • Antibody cloning experience highly desirable
  • Ability to analyze immunoglobulin NGS data and combine with other datasets to inform hit selection is highly desirable
  • Experience with microfluidics B cell cloning systems such as Berkeley Lights – Beacon is a plus
  • Experience cell biology FACS target-centric cell sorting or selection experience is a plus
  • In-depth knowledge of B/T cell biology and humoral and cell mediated immune responses is highly desirable
  • Experience with animal handling and manipulation of lymphoid tissues is highly desirable
  • Highly innovative and self-motivated
  • Excellent time management and organizational skills
  • Demonstrated ability to work in a multidisciplinary biologics discovery team


We strive to create an environment that will challenge, motivate, and reward our employees for meeting the changing demands of creating breakthrough therapeutics. Xencor has a highly collaborative structure that integrates co-workers with different skill sets into teams for product and technology development.  With an emphasis on attaining the best and most highly qualified candidates in their respective fields, we offer a competitive salary & benefits package. 


Physical Demands

The physical demands described are representative of those that must be met by an employee to successfully perform the primary functions of this position.


The physical demands of the office are normally association with extended amounts of time sitting and using office equipment, including a computer, keyboard and mouse, which can cause muscle strain. While performing the duties of this job, the employee is frequently required to stand, walk and sit. Periodic light lifting of supplies and materials may apply. Work is performed in an office environment.


Americans with Disabilities Act (ADA) Statement

The Company will provide reasonable accommodations (such as a qualified sign language interpreter or other personal assistance) with the application process upon your request as required to comply with applicable laws. If you have a disability and require assistance in this application process, please contact


To perform this job successfully, an individual must be able to perform each essential duty satisfactorily. Reasonable Accommodations may be made to enable qualified individuals with disabilities to perform the essential functions.


Equal Employment Opportunity (EEO) Statement

The Company is an equal opportunity employer, and all qualified applicants will receive consideration for employment without regard to age, race, color, religion, sex, sexual orientation, gender or gender identity, national origin, disability status, protected veteran status or any other characteristic protected by state or federal law.


Xencor does not accept profiles or resumes from recruiting vendors without a binding written agreement. Any unsolicited submission of services and or resumes in no way creates an obligation or duty by Xencor, implied or otherwise.


Thank You

Your application was submitted successfully.

  • Location
    Monrovia, California
  • Department
  • Employment Type
    Full Time
  • Minimum Experience