Group Leader / Associate Director - Protein Analytics

Research · Monrovia, California
Department Research
Employment Type Full Time
Minimum Experience Manager/Supervisor

Xencor is an innovative, clinical-stage biopharmaceutical company located in the Los Angeles area (near Pasadena) and in San Diego. We use our pioneering XmAb® technology to discover and develop better biotherapeutics – antibodies and other proteins with improved function – with the goal of improving patient outcomes and quality of life, and we have an excellent opportunity for a Protein Analytics – Group Leader / Associate Director to join our team.


Our capabilities and the modular nature of XmAb technology allows us to quickly identify and create new platforms and drug candidates for potential development. We are developing a deep pipeline of novel drug candidates enabled by the rapid expansion of our bispecific antibody and cytokine technologies. Nine XmAb bispecific antibody programs are in clinical testing, and more are expected to start clinical testing in 2021. We also leverage our many XmAb technologies by engaging in multiple collaborations with leading global biopharmaceutical companies, including Novartis, Amgen and Genentech, among others. We and our partners are advancing 18 XmAb drug candidates through clinical development, and two medicines that incorporate XmAb technology are approved for commercial marketing.

We are looking for a highly motivated leader to advance protein characterization efforts at Xencor. This is an exciting opportunity to make a significant impact advancing the therapeutic discovery. The successful candidate is expected to support development protein analytics efforts as Xencor. The candidate will collaborate closely with Antibody Discovery, biophysical characterization groups and therapeutic project leads to advance therapeutic molecule in the research and development portfolio.

Major Responsibilities

  • Expand the protein analytics efforts at Xencor
  • Hands on management of mass spectroscopy instrumentation and applications
  • Advance protein mass spectroscopy analytical methods including: intact mass analysis, peptide variant analysis and tandem MS-MS
  • Develop accelerated degradation methods to facilitate lead molecule design and selection.
  • Collaborate on biotherapeutics projects in close collaboration with a project lead - from conception to therapeutic candidate nomination
  • Collaborate with automation to increase efficiency and match future demand
  • Drive the science and contribute to the vision in the technology development
  • Excellent written and oral skills are necessary
  • Accomplish goals under project team timelines


  • Ph.D. in biochemistry or molecular biology and related fields with 4-8 years of industry experience or other relevant experience
  • High proficiency in mass spectroscopy and other protein analytical chemistry methods
  • Experience in glycoform analysis
  • Experience with UPLC / HPLC analytics and tandem techniques
  • Experience with working with and leading teams is essential
  • Highly innovative and self-motivated
  • Excellent time management and organizational skills
  • Demonstrated ability to work in a multidisciplinary research and discovery teams


We strive to create an environment that will challenge, motivate, and reward our employees for meeting the changing demands of creating breakthrough therapeutics. Xencor has a highly collaborative structure that integrates co-workers with different skill sets into teams for product and technology development.  With an emphasis on attaining the best and most highly qualified candidates in their respective fields, we offer a competitive salary & benefits package. 


Americans with Disabilities Act (ADA) Statement

The Company will provide reasonable accommodations (such as a qualified sign language interpreter or other personal assistance) with the application process upon your request as required to comply with applicable laws. If you have a disability and require assistance in this application process, please contact


To perform this job successfully, an individual must be able to perform each essential duty satisfactorily. Reasonable Accommodations may be made to enable qualified individuals with disabilities to perform the essential functions.


Equal Employment Opportunity (EEO) Statement

The Company is an equal opportunity employer, and all qualified applicants will receive consideration for employment without regard to age, race, color, religion, sex, sexual orientation, gender or gender identity, national origin, disability status, protected veteran status or any other characteristic protected by state or federal law.


Xencor does not accept profiles or resumes from recruiting vendors without a binding written agreement. Any unsolicited submission of services and or resumes in no way creates an obligation or duty by Xencor, implied or otherwise.

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  • Location
    Monrovia, California
  • Department
  • Employment Type
    Full Time
  • Minimum Experience