Lead Scientist, Bioanalytical Development

Bio-Analytical Development · Monrovia, California
Department Bio-Analytical Development
Employment Type Full Time
Minimum Experience Manager/Supervisor

Xencor is an innovative, clinical-stage biotechnology company located in the Los Angeles area (near Pasadena) and in San Diego. We use our pioneering XmAb® technology to discover and develop better biotherapeutics – antibodies and other proteins with improved function – with the goal of improving patient outcomes and quality of life, and we have an excellent opportunity for a Lead Scientist to join our team.

 

Our capabilities and the modular nature of XmAb technology allows us to quickly identify and create new platforms and drug candidates for potential development. We are developing a deep pipeline of novel drug candidates enabled by the rapid expansion of our bispecific antibody and cytokine technologies. Nine XmAb bispecific antibody programs are in clinical testing, and more are expected to start clinical testing in 2021. We also leverage our many XmAb technologies by engaging in multiple collaborations with leading global biopharmaceutical companies, including Novartis, Amgen and Genentech, among others. We and our partners are advancing 18 XmAb drug candidates through clinical development, and two medicines that incorporate XmAb technology are approved for commercial marketing.

  

We seek a Lead Scientist with expertise in the development, troubleshooting and validation of ligand binding immunoassays. This is a primary contributor and supervisory role. The title will be commensurate with qualifications, experience, and calibration. The incumbent will contribute to Xencor’s engineered protein therapeutic product research and development pipeline by providing expert scientific leadership and technical performance of bioanalytical methods for pharmacokinetics, immunogenicity, biomarkers, and potency.

 

 

Job Duties Include:

 

  • Apply scientific training and acumen to optimize and identify appropriate bioanalytical solutions for measuring and characterizing complex and challenging protein therapeutics and their serological responses.
  • Supervise and mentor a team of laboratory research associates and scientists
  • Data review, approval, analysis, graphing, reporting and presentation to internal and external audiences, including regulatory agencies
  • Represent Bioanalytical Development (BioAD) strategy and results to cross-functional research and drug development teams
  • Establish and maintain laboratory operations, including  SOPs and project management
  • Maintain current knowledge of the field and area(s) of scientific expertise and development

 

Qualifications/Requirements:

 

  • Ph.D. in Chemistry, Biochemistry or a related field with 5 or more years of experience in an industrial setting.
  • Extensive hands-on experience with the design, development, optimization, qualification, and validation of immunoassays across multiple platforms and technologies (e.g, ELISA, DELFIA, MSD)
  • Experience in and knowledge of GxP’s as relevant to laboratory practices in sample handling and analysis of GLP and GCP, specimens
  • Versed and proficient in industry guidance for the development and validation of ligand binding immunoassays and immunogenicity assays and critical reagent lifecycle management.
  • Excellent organizational and critical thinking  skills; attention to detail, adaptive learning and the ability to work well in a team
  • Strong written and oral communication skills with experience in authoring and reviewing technical reports and/or regulatory documents.
  • High competence in common software and data analysis packages (e.g., SoftMax Pro, WinNonLin, GraphPad Prism, JMP, Microsoft Office Suite)

 

We strive to create an environment that will challenge, motivate, and reward our employees for meeting the changing demands of creating breakthrough therapeutics. Xencor has a highly collaborative structure that integrates co-workers with different skill sets into teams for product and technology development.  With an emphasis on attaining the best and most highly qualified candidates in their respective fields, we offer a competitive salary & benefits package. Please submit a cover letter & resume.  For further information about Xencor, please visit our website atwww.xencor.com   EOE

 

 

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  • Location
    Monrovia, California
  • Department
    Bio-Analytical Development
  • Employment Type
    Full Time
  • Minimum Experience
    Manager/Supervisor