Senior Director/Director, Oncology Program Leadership and Alliance Management

Project Leadership & Alliance Management · San Diego, California
Department Project Leadership & Alliance Management
Employment Type Full Time
Minimum Experience Executive

Xencor is an innovative, clinical-stage biopharmaceutical company located in the Los Angeles area (near Pasadena) and in San Diego. We use our pioneering XmAb® technology to discover and develop better biotherapeutics – antibodies and other proteins with improved function – with the goal of improving patient outcomes and quality of life, and we have an excellent opportunity for a Senior Director/Director,  Oncology Program Leadership and Alliance Management to join our team.


Our capabilities and the modular nature of XmAb technology allows us to quickly identify and create new platforms and drug candidates for potential development. We are developing a deep pipeline of novel drug candidates enabled by the rapid expansion of our bispecific antibody and cytokine technologies. Nine XmAb bispecific antibody programs are in clinical testing, and more are expected to start clinical testing in 2021. We also leverage our many XmAb technologies by engaging in multiple collaborations with leading global biopharmaceutical companies, including Novartis, Amgen and Genentech, among others. We and our partners are advancing 18 XmAb drug candidates through clinical development, and two medicines that incorporate XmAb technology are approved for commercial marketing.


We seek a Senior Director/Director, Program and Alliance Management, with 10 or more years of experience in biotechnology product development programs. The incumbent will oversee the program management of a portfolio of monoclonal antibody therapeutic candidates in oncology and/or autoimmune diseases by coordinating all aspects of development to advance assets from pre-clinical through advanced phases of clinical development. 


Job Duties include:

  • Leadership of a cross-functional team which is accountable for the development of therapeutic products in a global, matrix organization, from Discovery to life cycle management. 
  • Responsibility for construction and maintenance of Integrated Development Plans, written in partnership with the program team and key experts.
  • Accountability for management of project plans (in Smartsheet or MSP) that deliver the integrated development plan within agreed budget and timelines.
  • Influence functional team members to deliver on activities as necessary to achieve program goals
  • Provide periodic status reports to executives and coordinate documentation and archiving of project deliverables.
  • Build and drive a project team through clear designation of team roles, responsibilities, clear work scope and coordination of efforts.
  • Communicate effectively across all functional groups so that schedules and scope of the project is clear.
  • Provide alliance management support to one or more external partnerships
  • Willingness to travel to Monrovia and San Diego as needed


Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.


Please note this job description is not designed to cover or contain a comprehensive listing of activities, duties or responsibilities that are required of the employee for this job. Duties, responsibilities and activities may change at any time with or without notice.


  • 10+ years in Program or Project Leadership in biotech or pharma 
  • Life Science MS or equivalent biotech industry experience required, MBA or PhD a plus
  • Pre-IND to Phase 1/2 experience required
  • Preferred areas of knowledge include oncology or autoimmune disease expertise, monoclonal antibody expertise, global IND/BLA requirements.
  • Proven success with managing challenging, team-based problem solving and program tracking. 
  • Demonstrated ability and success using written and verbal communication skills to communicate complex scientific, medical and program issues
  • Detail oriented, but also values that details serve the higher level strategy
  • Alliance experience preferred, or strong desire to learn alliance management skills
  • Confident and professionally outspoken while valuing and respecting functional SME’s. 
  • Ability to partner with cross-functional team from research, pre-clinical development, manufacturing, quality, regulatory and clinical development.
  • Proven leadership, influencing capability and active facilitation skills to enable effective team meetings and high performance teams
  • Outstanding flexibility and adaptability suited for the changing requirements and fast-pace of a small biotechnology company
  • Expertise in Smartsheet and/or Microsoft Project


We strive to create an environment that will challenge, motivate, and reward our employees for meeting the changing demands of creating breakthrough therapeutics. Xencor has a highly collaborative structure that integrates co-workers with different skill sets into teams for product and technology development.  With an emphasis on attaining the best and most highly qualified candidates in their respective fields, we offer a competitive salary & benefits package. Please submit a cover letter & resume.  For further information about Xencor, please visit our website at   EOE


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  • Location
    San Diego, California
  • Department
    Project Leadership & Alliance Management
  • Employment Type
    Full Time
  • Minimum Experience