Xencor is an innovative, clinical-stage biotechnology company located in the Los Angeles area (near Pasadena) and in San Diego. We use our pioneering XmAb® technology to discover and develop better biotherapeutics – antibodies and other proteins with improved function – with the goal of improving patient outcomes and quality of life, and we have an excellent opportunity for a Senior Research Associate/Associate Scientist – In Vivo Pharmacology to join our team.
Our protein engineering capabilities and the modular nature of our technology allow us to quickly identify and create new platforms and drug candidates for potential development. We are developing a broad portfolio enabled by the rapid expansion of our bispecific technologies, and nine XmAb bispecific antibodies and cytokines are in clinical testing. We also leverage our many XmAb technologies by engaging in multiple collaborations with leading global biopharmaceutical companies, including Novartis, Amgen and Genentech, among others. Including our partners, over a dozen XmAb drug candidates are advancing through clinical development, and the first antibody that incorporates an XmAb technology has been approved for commercial marketing worldwide.
Our employees are the most important factor in our success and we have assembled a highly talented group from diverse backgrounds and disciplines to execute our business plan and shape our future. Xencor employees value new ideas and flexibility and demand from each other scientific rigor, a passion for innovation, and a willingness to take risks.
Responsibilities and Job Specifications:
Xencor, an innovative and successful biopharmaceutical company located in Southern California, is looking for a highly experienced and motivated scientist to complement our pharmacology department.
Xencor is currently looking for an experienced in vivo pharmacology scientist. The candidate will work under minimal supervision to implement, execute, supervise and report in vivo pharmacology studies focused on identifying therapeutic antibody and protein candidates in the areas of oncology, inflammation and autoimmune disease.
In vivo responsibilities will include disease induction, huPBMC purification from donor blood, test article and reagent formulation, dosing (by all major routes), tumor measurement, blood collection via retro-orbital sinus, serum processing, tissue collection, animal husbandry, and monitoring of animal health. In addition, candidate will be responsible for sample processing, data collection and analyses (graphing, statistics, etc.), generation of draft study protocols/reports, training/supervision of junior scientists and detailed record keeping.
Candidate will report directly to the Pharmacology Associate Director and provide him/her with regular data/status updates.
Other required skills include mammalian cell culture (aseptic preparation of media, freezing and thawing of cells, expanding/splitting cells for in vivo implantation), experience managing in vivo study teams, experience with Microsoft Excel, GraphPad Prism and StudyLog. Candidate will be required to handle human tissue samples. In vivo imaging and PDX model expertise are desirable.
Candidate will work with highly motivated research scientists in a goal-oriented multi-project environment. In addition, the candidate must be well-organized, detail-oriented, able to work both independently and in a team setting, have excellent oral and written communication skills and be available for work on weekends.
Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
Please note this job description is not designed to cover or contain a comprehensive listing of activities, duties or responsibilities that are required of the employee for this job. Duties, responsibilities and activities may change at any time with or without notice.
A minimum of a Bachelor's degree in biology or a related field, with 5+ years of relevant pharmaceutical or biotechnology industry experience with cancer xenograft, inflammation and/or autoimmunity mouse models is required.
The physical demands described are representative of those that must be met by an employee to successfully perform the primary functions of this position.
The physical demands of the office are normally association with extended amounts of time sitting and using office equipment, including a computer, keyboard and mouse, which can cause muscle strain. While performing the duties of this job, the employee is frequently required to stand, walk and sit. Periodic light lifting of supplies and materials may apply. Work is performed in an office environment.
We strive to create an environment that will challenge, motivate, and reward our employees for meeting the changing demands of creating breakthrough therapeutics. Xencor has a highly collaborative structure that integrates co-workers with different skill sets into teams for product and technology development. With an emphasis on attaining the best and most highly qualified candidates in their respective fields, we offer a competitive salary & benefits package. Please submit a cover letter & resume. For further information about Xencor, please visit our website at www.xencor.com EOE
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