Manager, Environmental Health & Safety

Cell Biology · Monrovia, California
Department Cell Biology
Employment Type Full Time
Minimum Experience Manager/Supervisor


Xencor is an innovative, clinical-stage biotechnology company located in the Los Angeles area (near Pasadena) and in San Diego. We use our pioneering XmAb® technology to discover and develop better biotherapeutics – antibodies and other proteins with improved function – with the goal of improving patient outcomes and quality of life, and we have an excellent opportunity for  a Manager, Environmental Health & Safety to join our team.

Our protein engineering capabilities and the modular nature of our technology allow us to quickly identify and create new platforms and drug candidates for potential development. We are developing a broad portfolio enabled by the rapid expansion of our bispecific technologies, and nine XmAb bispecific antibodies and cytokines are in clinical testing. We also leverage our many XmAb technologies by engaging in multiple collaborations with leading global biopharmaceutical companies, including Novartis, Amgen, and Genentech, among others. Including our partners, over a dozen XmAb drug candidates are advancing through clinical development, and the first antibody that incorporates an XmAb technology has been approved for commercial marketing worldwide.

Our employees are the most important factor in our success and we have assembled a highly talented group from diverse backgrounds and disciplines to execute our business plan and shape our future. Xencor employees value new ideas and flexibility and demand from each other scientific rigor, a passion for innovation, and a willingness to take risks.

We seek a Manager, Environmental Health & Safety to lead, implement, and maintain effective environmental, health, and safety programs and procedures, ensuring a safe work environment and compliance with all federal, state and local regulations in both our laboratories and offices.   


Job Duties include:

  • Responsible for all aspects of the environmental, health and safety program; including but not limited to training, incident investigations, emergency planning, auditing/inspections and developing action plans for management
  • The development, review, update and management of EH&S written policies and procedures to ensure compliance with federal, state, and local laws, regulations, rules and industry best practices
  • Identify, assess and recommend risk assessments, control measures and corrective action(s) for environmental, health and safety concerns
  • Oversee emergency response projects such as the company’s COVID-19 preparedness and readiness programs to ensure Xencor sites are compliant and safe; including evaluating/selecting effective PPE, and implementing new processes and procedures to ensure all relevant workplace protections are in place
  • Lead projects & evaluate processes in the anticipation, recognition, evaluation and control of occupational health, safety and environmental regulations
  • Develop and deliver both regular general safety, and lab-specific safety training programs
  • Conduct jobsite assessments, focusing on unsafe conditions and unsafe work behaviors; ensure appropriate action is taken to correct deficiencies
  • Champion safety activities and be a resource to safety representatives and management
  • Participate in Occupational Safety and Health Administration (OSHA) inspections and in any procedures that may follow a citation
  • Monitor and maintain records and permits of hazardous and biohazardous materials and waste in compliance with all applicable local, state and federal regulations
  • Conduct periodic review of policies, programs, and metrics to ensure alignment of EH&S strategies with business needs
  • Keep abreast of the state and federal regulations affecting Xencor’s business; initiating changes to practices and procedures to support compliance requirements
  • Acts as chair of safety committee, maintaining visibility of the safety program and open lines of communications with all employees in regard to workplace safety
  • Train and coach managers and supervisors regarding effective loss prevention techniques utilizing multidisciplinary strategies - incident investigation, hazard identification, self-inspection and associate training
  • Responsible for environmental programs such as waste streams, including solid (e.g. biological/hazardous) liquid and airborne emissions
  • Conduct EHS audits, inspections, hazard assessments and investigations as required and make appropriate and timely recommendations based off findings
  • Lead incident and accident investigations assuring corrective actions are taken to address, and minimize or prevent similar future incidents
  • Responsible for current knowledge of local, state and federal regulations including but not limited to OSHA, EPA, FDA, etc.
  • Maintain recordkeeping per OSHA requirements for accidents and injuries
  • Plan and schedule corrective and preventive work orders
  • Work with site planning for changes that could affect HVAC performance
  • Assist in the selection and monitor the performance of outside contractors and vendors
  • Manage biological and chemical safety in laboratories specifically on the safe use and storage of materials, management of waste, and general safety
  • Coordinate investigations and activities associated with pollution remediation
  • Provide technical support for EHS software programs and processes.

Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.


Please note this job description is not designed to cover or contain a comprehensive listing of activities, duties or responsibilities that are required of the employee for this job. Duties, responsibilities, and activities may change at any time with or without notice.




  • BS in Environmental, Occupational Safety and Health or related is preferred with a minimum of 5 years of life science/ biotechnology EH&S experience (an equivalent combination of education and experience may be considered)
  • Knowledge of and experience in EHS management systems, best practices and cGMP
  • Certified Safety Professional (CSP) or Associate Safety Professional (ASP) certification preferred
  • Knowledge of federal and state regulations, life science/biotechnology industry standards pertaining to occupational health & safety
  • Experience handling and managing RCRA hazardous waste
  • Professional safety tools/knowledge such as ergonomics, management skills, industrial hygiene, presentation skills, etc. to convey and improve safety
  • Knowledge of hazardous materials management, environmental regulations
  • Technical and practical knowledge of biotechnology, research, and development
  • Demonstrated understanding of federal and state safety and environmental laws and the ability to identify and evaluate workplace hazards required
  • Good interpersonal skills: ability to develop relationships quickly and effectively at all levels throughout the company
  • Ability to work with people in a diverse environment across functions and departments
  • Excellent communication skills (written, oral and presentation.)

Physical Demands:


The physical demands described are representative of those that must be met by an employee to successfully perform the primary functions of this position.


The physical demands of the office are normally association with extended amounts of time sitting and using office equipment, including a computer, keyboard, and mouse, which can cause muscle strain. While performing the duties of this job, the employee is frequently required to stand, walk, and sit. Periodic light lifting of supplies and materials may apply. Ability to Adjust, lift and move objects up to 50 pounds. Operating machinery and/or power tools

We strive to create an environment that will challenge, motivate, and reward our employees for meeting the changing demands of creating breakthrough therapeutics. Xencor has a highly collaborative structure that integrates co-workers with different skill sets into teams for product and technology development.  With an emphasis on attaining the best and most highly qualified candidates in their respective fields, we offer a competitive salary & benefits package. Please submit a cover letter & resume.  For further information about Xencor, please visit our website at   EOE


Xencor does not accept profiles or resumes from recruiting

vendors without a binding written agreement.


Any unsolicited submission of services and or resumes in no way

creates an obligation or duty by Xencor, implied or otherwise.


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  • Location
    Monrovia, California
  • Department
    Cell Biology
  • Employment Type
    Full Time
  • Minimum Experience