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Xencor

Lead Scientist, Preclinical PK/PD/Toxicology

Preclinical Development – Monrovia, California
Department Preclinical Development
Employment Type Full Time

Xencor is an innovative, clinical-stage biotechnology company located in the Los Angeles area (near Pasadena) and in San Diego. We use our pioneering XmAb® technology to discover and develop better biotherapeutics – antibodies and other proteins with improved function – with the goal of improving patient outcomes and quality of life, and we have an excellent opportunity for a Lead Scientist, Preclinical PK/PD/Toxicology.

Our capabilities and the modular nature of our technology allow us to quickly identify and create new platforms and drug candidates for potential development. We are developing a deep pipeline of novel drug candidates enabled by the rapid expansion of our bispecific technologies, and seven XmAb bispecific antibody programs are in clinical testing. We also leverage our many XmAb technologies by engaging in multiple collaborations with leading global biopharmaceutical companies, including Novartis, Amgen and Genentech, among others. Including our partners, over a dozen XmAb drug candidates are advancing through clinical development, and the first antibody that incorporates an XmAb technology has been approved for commercial marketing in the United States.

Our employees are the most important factor in our success and we have assembled a highly talented group from diverse backgrounds and disciplines to execute our business plan and shape our future. Xencor employees value new ideas and flexibility and demand from each other scientific rigor, a passion for innovation, and a willingness to take risks.

We are seeking an in vivo Pharmacokinetics, Pharmacodynamics, Toxicology (PK/PD/Tox) scientist to design and execute Preclinical drug development studies evaluating and informing lead clinical candidate selection for engineered antibody therapeutics focused primarily, but not exclusively, on immuno-oncology.  This is a Project Team Representative role that liaises with Xencor discovery and development project teams to design, analyze, and interpret in vivo studies performed at contract laboratories. The role does not include research pharmacology or animal models of disease. Grade level to be commensurate with experience and internal calibration.

 This position reports to the Senior Director, Preclinical.

 Some responsibilities include:

  • Interacts with other functional area experts in a project team environment to recommend the best course of preclinical development for a given program and defend those recommendations to executive management.
  • Designs appropriate PK/PD and toxicology studies to support large molecule drug development
  • In partnership with a study monitor, provides scientific leadership, oversight, and approval of studies implemented at contract laboratories
  • Applies and/or procures appropriate platforms and strategies such as physiologically-based pharmacokinetic (PBPK) modeling and simulation, Non-Compartmental and Compartmental PK simulation
  • Analyzes and interprets results and makes recommendations to teams and senior management
  • Prepare study reports and appropriate sections of the common technical documents for regulatory submission and queries on development candidates Potentially interacts with health authorities
  • Maintain current knowledge of the field and area(s) of scientific expertise and development

 Qualifications:

  • DVM or PhD in Pharmacokinetics, Toxicology, or related science with a minimum of 3 years’ experience in large molecule/biologics drug development
  • Exceptional non-PhDs with demonstrated capabilities and/or significant experience may also be considered
  • Certification in Toxicology (DABT) is desired
  • Experience sourcing and/or monitoring non-human primate preclinical projects at a contract laboratory
  • Knowledge and experience in Good Laboratory Practices (GLPs)
  • High functionality in MS Office (Word, Excel, Outlook, PowerPoint) and data analysis and graphing software (eg, WinNonLin, GraphPad Prism, SpotFire, JMP)
  • Exceptional verbal and written communication skills; ability to communicate clearly and effectively with scientific colleagues and senior management
  • Must be able to demonstrate sound theoretical and experimental background in biology coupled with technical proficiency, scientific creativity, collaboration with others and independent thought
  • Excellent organizational, documentation, negotiation and interpersonal skills; adaptive learning and critical thinking
  • Thrives in an entrepreneurial environment with initiative and flexibility in delivering independent and matrixed team contributions

Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions. 

*Please note this job description is not designed to cover or contain a comprehensive listing of activities, duties or responsibilities that are required of the employee for this job. Duties, responsibilities and activities may change at any time with or without notice.

Xencor does not accept profiles or resumes from recruiting vendors without a binding written agreement.

Any unsolicited submission of services and or resumes in no way creates an obligation or duty by Xencor, implied or otherwise.

 

 

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  • Location
    Monrovia, California
  • Department
    Preclinical Development
  • Employment Type
    Full Time
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