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Xencor

Associate Director/Director, Translational Biology

Preclinical Development – Monrovia or San Diego , California
Department Preclinical Development
Employment Type Full Time
Minimum Experience Senior Manager/Supervisor

 Xencor Inc. is an innovative biotechnology company located in the Los Angeles area (near Pasadena) and in San Diego.  We have a very deep drug development pipeline including six programs currently in clinical testing with two more expected to start clinical testing by 1H2019 and have an excellent opportunity for an Associate Director/Director of Translational Biology to join our team.  We use our pioneering XmAb® technology to develop better biotherapeutics – antibodies that target new biological mechanisms and have the potential to be more potent, safer and longer lasting – with the goal of improving patient outcomes and quality of life.  In addition to generating a pipeline of novel drug candidates, with twelve in clinical testing by Xencor or our partners, our XmAb® technology has enabled multiple collaborations with leading biopharmaceutical companies including Novartis, Amgen,  Morphosys, CSL, Alexion and Boehringer Ingelheim. 

Our employees are the most important factor in our success and we have assembled a highly talented group from diverse backgrounds and disciplines to execute our business plan and shape our future. Xencor employees value new ideas and flexibility and demand from each other scientific rigor, a passion for innovation, and a willingness to take risks.  We seek an Associate Director/Director of Translational Biology, with title commensurate with experience to drive the biomarker analysis in clinical biospecimens in clinical studies using Xencor bispecific antibodies (T cell engagers, checkpoints, targeted and engineered cytokines).

Job Duties include:

The Director/Associate Director, Translational Biology, acts as an independent scientist responsible for coordinating the analysis of genomics/transcriptomics/immunobiological data for preclinical studies and clinical studies. This person interacts with all members of the Translational Biology, Biometrics, Pre-Clinical and Clinical Development teams, and is accountable for the oversight and quality of analysis of immunobiological data (flow cytometry/multiplex immunofluorescence/cytokines) for clinical samples and genomics/transcriptomics data for pre-clinical science and clinical samples. Responsibilities may include some or all of the following:

Plan, implement and manage biomarker projects with outside laboratories

Champion analysis of genomics/transcriptomics for tumor biopsies and peripheral blood samples

Participate with preclinical projects that require genomic/transcriptomic analysis of cultured cells or tissues/blood from animal models

Lead contact on high dimensional data sets, e.g., transcriptomics of clinical trials 

Ensure that clinical biomarker data is scientifically rigorous and supports clinical development

Manage a shared biostatistician with expertise in programming for high dimensional data sets, e.g., transcriptomics/genomics data Present pre-clinical data and the relevant literature at internal meetings 

Effectively manage projects as part of a multidisciplinary team

Contribute to publications and presentations

Represent supported projects at scientific conferences

Leads interactions with investigators and cooperative groups

Attends 3-4 scientific meeting or off-site meetings per year

Other duties as assigned

Deep understanding of complex cellular signaling pathways 

Data review, writing and interpretation

Ability to work effectively with a cross-functional study team

Ability to manage multiple (3-5) projects simultaneously, set and meet deadlines

Ability to analyze complex flow cytometric data, transcriptomics (including Nanostring and RNAseq) and multiplex immunofluorescence. 

Excellent oral and written communication skills

Please note this job description is not designed to cover or contain a comprehensive listing of activities, duties or responsibilities that ae required of the employee for this job.  Duties, responsibilities and activities may change at any time with or without notice.

Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Please note this job description is not designed to cover or contain a comprehensive listing of activities, duties or responsibilities that are required of the employee for this job. Duties, responsibilities and activities may change at any time with or without notice.

Qualifications/Requirements:

Advanced Clinical/Science Degree (e.g. PharmD, PhD, Postdoctoral)

Experience in pre-clinical/translational drug discovery, demonstrated strong achievements in academic and industry settings

Minimum 5 years pre-clinical development experience in the pharmaceutical or biotechnology industry, 2 years may be sufficient for candidates with translational postdoctoral experience

Knowledge of international regulations pertinent to current clinical development (eg ICH, FDA, EMA)

Ability to analyze complex flow cytometric data (FloJo), transcriptomics (including Nanostring and RNAseq) and multiplex immunofluorescence

Understanding of immunobiology and eagerness to work with clinical immunoncology data

Highly advanced oral, writing and presentations skills

Organized and able to set/meet deadlines

Ability to work collaboratively in a team of people with different backgrounds and seniority levels

We strive to create an environment that will challenge, motivate, and reward our employees for meeting the changing demands of creating breakthrough therapeutics. Xencor has a highly collaborative structure that integrates co-workers with different skill sets into teams for product and technology development.  With an emphasis on attaining the best and most highly qualified candidates in their respective fields, we offer a competitive salary & benefits package. Please submit a cover letter & resume.  For further information about Xencor, please visit our website atwww.xencor.com   EOE

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  • Location
    Monrovia or San Diego , California
  • Department
    Preclinical Development
  • Employment Type
    Full Time
  • Minimum Experience
    Senior Manager/Supervisor
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